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Ahumada-Del Castillo Syndrome

Ahumada-Del Castillo is a rare endocrine disorder affecting adult females, which is characterized by impairment in the function of the pituitary and hypothalamus glands. Women with this disorder have breasts and nipples of normal size and appearance. Secondary female characteristics, such as hair distribution and voice, are also normal. Since ovaries do not produce eggs; therefore, affected females cannot become pregnant. Symptoms may include the production of breast milk (lactation) not associated with nursing and the absence of menstrual periods (amenorrhea) due to the lack of monthly ovulation (anovulation). A disorder characterized by galactorrhea and amenorrhoea. Three types are reecognized:

Chiari-Frommel syndrome: persistent galactorrhoea and amenorrhea after giving birth.

Ahumada-Del Castillo syndrome: galactorrhoea-amenorrhoea not associated with pregnancy. There is oestrogen deficiency and decreased urinary gonadotropin levels.

Forbes-Albright syndrome: galactorrhea-amenorrhea caused by a chromophobe prolactin-producing adenoma of the pituitary

Causes of Ahumada Del Castillo syndrome

The exact cause of Ahumada-Del Castillo Syndrome is not known. Some research suggests that small tumors in the pituitary or hypothalamus glands may be responsible for some cases. These tumors are frequently microscopic and extremely difficult to detect. Rarer causes of Ahumada-Del Castillo Syndrome may be associated with low levels of thyroid function (hypothyroidism), chronic use of dopamine-antagonistic drugs (i.e., chlorpromazine or thorazine), and discontinuation of oral contraceptives (birth control pills).

Treatment and Cure of Ahumada Del Castillo syndrome

Areas of Ahumada Del Castillo syndrome do not lend themselves to local surgical excision. The only definitive treatment for Ahumada Del Castillo syndrome, therefore, is total hysterectomy (surgical removal of the entire uterus). Temporary relief of very painful heavy periods can be achieved with GnRH agonists such as Lupron.

The measures / treatment of Ahumada Del Castillo syndrome on the physical side should include a well- ordered hygienic mode of living, a nutritious and bland diet, adequate mental and physical rest, daily exercise , agreeable, occupation, fresh air, regular hours of eating and sleeping, regulation of the bowels and wholesome companionship with others.


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