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Necrobiosis Lipoidica Diabeticorum - Symptoms and Treatment

Necrobiosis lipoidica diabeticorum is a degenerative disease of the connective tissue in the skin. It usually occurs on the lower part of the legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Often a biopsy is needed to diagnose nld. NLD usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes. Still, the exact cause of nld in not known. A similar condition that is often confused with NLD is granuloma annulare. Similar to the association of NLD and diabetes, it appears that a high percentage of persons with disseminated granuloma annulare have diabetes mellitus. The individual spots typically consist of a circular array of reddish to brown and slightly translucent bumps. Sometimes it responds to topical cortisone creams, especially if covered with an airtight dressing. Cortisone injections can also be used to treat NLD. These are more effective than cortisone creams. NLD usually goes through stages of activity and inactivity. One is not able to predict when the condition will flare. Ultraviolet light treatment has been found to control this condition when it is flaring. A baby aspirin each day, and other medications that thin the blood, such as Trental, may help NLD. Other medications, including prednisone pills (steroids) are used in difficult or severe cases.

Causes of Necrobiosis Lipoidica Diabeticorum

Common Causes of Necrobiosis Lipoidica Diabeticorum :

  • Necrobiosis lipoidica diabeticorum, may be caused by trauma , inflammatory and metabolic changes.
  • The main cause of necrobiosis lipoidica diabeticorum is diabitic microangiopathy .
  • A deposition of glycoprotein in blood vessel walls may be the cause of diabetic microangiopathy, which in turn lead to necrobiosis lipoidica diabeticorum.
  • Still other theories suggest that an antibody-mediated vasculitis may cause the changes seen in Necrobiosis lipoidica diabeticorum.
  • Necrobiosis lipoidica diabeticorum usually occurs in patients with diabetes.

Symptoms of Necrobiosis Lipoidica Diabeticorum

Some common Symptoms of Necrobiosis Lipoidica Diabeticorum :

  • Skin lesions.
  • Rash.
  • Face and scalp.
  • Burning and painful.

Treatment of Necrobiosis Lipoidica Diabeticorum

  • It can be treated by applying ultraviolet light therapy , when it is flaring.
  • The topical cortisone injections into the lesion are found very effective in the treatment of necrobiosis lipoidica diabeticorum.
  • Some medications such as aspirin , fibrinolytic agents, nicotinamide , pentoxifylline, heparin , antiplatelet agents, ticlopidine , tretinoin , and cyclosporine are also very helpful in the treatment of necrobiosis lipoidica diabeticorum.
  • Oral aspirin, pentoxifylline, dipyridamole, locally injected steroids, and systemic steroids
  • Sometimes necrobiosis lipoidica diabeticorum responds to topical cortisone preparations.








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