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Aplastic Hypoplastic Anemias

Aplastic anemia, or hypoplastic anemia, results from conditions in which blood cell production in the bone marrow or erythrocyte stem cells are underdeveloped, defective, or absent. Aplastic anemia is a syndrome of bone-marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. Acquired cases of aplastic anemia are almost all idiopathic and arise from unknown causes.

Other cases of aplastic anemia are secondary and are caused by radiation, chemicals or viruses. The term aplastic anemia commonly implies a panhypoplasia of the marrow with associated leukopenia and thrombocytopenia. The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. It is possible that the main title of the report Anemia, Blackfan Diamond is not the name you expected.

Causes of Aplastic Hypoplastic Anemias

There are various factors which give rise to the disease Aplastic Hypoplastic Anemias , but here we mentioned some of the common causes:

    • Fanconi anemia.
    • Dyskeratosis congenita.
    • Cartilage hair hypoplasia.
    • Pearson syndrome.
    • Amegakaryocytic thrombocytopenia.
    • Shwachman-Diamond syndrome.
    • Dubowitz syndrome.
    • Diamond-Blackfan syndrome.
    • Familial aplastic anemia

Symptoms of Aplastic Hypoplastic Anemias

Some of the common sign and symptoms of the disease Aplastic Hypoplastic Anemias are as follows:

  • A progressive weakness and fatigue.
  • Shortness of breath.
  • Headache.
  • Pallor,; and ultimately.
  • Tachycardia and congestive heart failure.

Treatment of Aplastic Hypoplastic Anemias

Find effective treatment methods of treating Aplastic Hypoplastic Anemias:

  • Removing any identifiable cause and preventing further exposure to the causal agent is the most important aspect.
  • Splenectomy is considered if transfused erythrocytes are being destroyed in the spleen.
  • Bone marrow transplantation is the treatment of choice for severe aplasia and for those who need constant RBC replacement.
  • Sometimes, pharmacologic stimulation of the marrow function is tried; but these immunosuppressive drugs have some serious side effects.
  • Antibiotics are not given prophylactically because they tend to encourage resistant strains of organisms.



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