Inclusion Body Myositis

Sporadic inclusion body myositis ( sIBM ) is an inflammatory muscle disease , characterized by slowly progressive weakness and wasting of the distal and proximal muscles, most apparent in the muscles of the arms and legs . The onset of muscle weakness in IBM is generally gradual (over months or years). Falling and tripping are usually the first noticeable symptoms. These tests can be either an elevated creatinine phosphokinase (CPK) or an elevated aldolase. In addition EMG/ Nerve Conduction Studies will reveal evidence for a muscle disease. The degeneration aspect is characterized by the appearance of holes in the muscle (vacuoles), deposits of amyloid-related proteins within the cells and filamentous inclusions (hence the name inclusion body myositis) of abnormal proteins. Atrophy or shrinking of the forearms is also characteristic. Difficulty swallowing (dysphagia) occurs in approximately half of IBM cases.

Inclusion body myositis is a disease of muscle that causes muscles to become thin and weak. . This is very important because IBM can look like polymyositis or even adult onset muscular dystrophies. The inflammation aspect is characterized by the cloning of cells that appear to be driven by specific antigens to invade muscle fibers Nevertheless, it is sufficiently rare that most general practitioners will not have looked after patients with inclusion body myositis before, and many doctors will not have heard of the condition. Patients may become unable to perform daily living activities and most require assistive devices within 5 to 10 years of symptom onset.Unfortunately at present there is no known cause for this disease.

Causes of Inclusion Body Myositis

The common causes of Inclusion Body Myositis :

• Current research suggests that the condition might occur when immune system cells infiltrate and attack muscle tissue (an autoimmune process)

• Alanine transaminase levels raised (plasma or serum)
• Lactate dehydrogenase levels raised (plasma or serum)
• inflammation of the wall of the aorta

Symtoms of Inclusion Body Myositis

Some are common symtoms of Inclusion Body Myositis :

• This signs and symptoms information for Inclusion Body Myositis has been gathered from various sources, may not be fully accurate, and may not be the full list of Inclusion Body Myositis signs or Inclusion Body Myositis symptoms
• Other diseases with similar symptoms and common misdiagnoses
• Blurred Vision or Double Vision
• Sensitivity to Light and Loss of Sensation
• Finger muscle weakness

Treatment of Inclusion Body Myositis

The most important Treatment of Inclusion Body Myositis :

• The natural history of the disease is for stabilization or improvement in a third of patients for 6 months or more
• Some evidence suggests that intravenous immunoglobulin may have a slight, but transient, beneficial effect in a small number of cases.

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