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Crohn's Disease

Crohn's disease is an ongoing disorder that causes inflammation of the digestive tract, also referred to as the gastrointestinal (GI) tract It can affect any part of your digestive tract, but it is most common in the last part of the small intestine (ileum) and the large intestine (colon). Other symptoms include losing weight, feeling sick to your stomach, having joint pain and feeling tired. Crohn's disease affects the deepest layers of the lining of the digestive tract, causing deep sores called ulcers. They affect approximately 500,000 to 2 million people in the United States. Men and women are equally affected. About 20 percent of people with Crohn's disease have a blood relative with some form of inflammatory bowel disease, most often a brother or sister and sometimes a parent or child. and a similar condition called ulcerative colitis are referred to together as inflammatory bowel diseases . Crohn's disease and ulcerative colitis (which affects the colon and rectum) are the most common types of inflammatory bowel disease, with ulcerative colitis being more common.

A small number of patients have involvement of the mouth (apthous ulcers) or upper intestinal tract. Unlike ulcerative colitis, Crohn's disease is a transmural process that can result in mucosal inflammation and ulceration, stricturing, fistula development, and abscess formation. Cigarette smoking is strongly associated with the development of Crohn's disease, resistance to medical therapy, and early disease relapse.

Crohn disease is a chronic (slowly developing, long-term) inflammation of the digestive tract.. It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus. It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus. Symptoms include stomach cramps and pain that comes and goes, diarrhea and blood in your stool. is named after the physician who described the disease in 1932. It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis. Crohn's disease usually affects the small intestine, particularly the last section (called the ileum), but any part of the digestive tract can be affected from the mouth to the anus These illnesses are known for their unpredictable flares and remissions. Ulcerative colitis, on the other hand, usually affects only the innermost lining of your large intestine (colon) and rectum. However, therapies are available that may greatly reduce the signs and symptoms of Crohn's disease and even bring about a long-term remission

Causes of Crohn's Disease

  • Immunological disorder- Not proven 
  • Diet- Not proven, although some people find it's better to avoid certain foods
  • Probably the most popular theory is that Crohn disease is caused by the immune system overreacting to infection by a virus or bacterium
  • Crohn disease apparently is not caused by emotional distress.


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