Abarelix

Brand Names

• Plenaxis

General Information

Abarelix is a type of medicine called a gonadotropin-releasing hormone antagonist that lowers the male hormone testosterone in your blood.It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. Other treatments for prostate cancer should be tried before treatment with abarelix is prescribed. Early stage prostate cancer is often treated with surgery or radiation therapy and less often with cryoablation. Advanced stage prostate cancer may be treated with other drugs that decrease the production of testosterone. Abarelix may also be used for purposes other than those listed in this medication guide. In some cases, the use of abarelix has resulted in serious allergic reactions. An allergic reaction may occur after any injection of the medication, including, but not limited to the first dose. Abarelix is highly bound to plasma proteins and shows an apparent volume of distribution of over 4000 L, suggesting extensive distribution throughout the body. Generic abarelix injection is not available.

Abarelix Dosage

• The recommended dose of PlenaxisT is 100 mg administered intramuscularly to the buttock on Day 1, 15, 29 and every 4 weeks thereafter.
• Abarelix is usually given every 2 weeks for the first 3 doses, then once every 4 weeks thereafter, or as directed by your doctor.

Side Effects of Abarelix:

The following side effects of Abarelix may includes:

• Fast or irregular breathing.
• Hot flushes.
• Diarrhea.
• Hemophilia.
• Swelling of eyes or eyelids.
• Headache.

Warning and precautions before taking Abarelix:

• It is very important that your doctor check you at regular visits.
• Do not use this medication if you are pregnant or if you could become pregnant during treatment.
• Patients should inform their physician of any known drug or food allergies or any reactions to medications they have experienced in the past.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Overdosage:

• An overdose of Plenaxis (abarelix) is unlikely to occur. The maximum tolerated dose of PlenaxisT has not been determined.
• If you do suspect that an overdose has occurred, contact your doctor, hospital emergency room, or poison control center for advice.
• US residents can call the US national poison hotline at 1-800-222-1222.

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