Baclofen is a muscle relaxant and an antispastic agent. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis or certain injuries to the spine. Baclofen can also be used to treat hiccups. Baclofen can be administered either orally or intrathecally (directly into the spinal fluid). Intrathecal administration is often indicated in spasticity patients, as very little of the oral dose actually reaches the spinal fluid. The exact way that baclofen works is unknown. It is available in tablet, oral liquid and injection form. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform. Baclofen affects the spinal cord, which is the main connection between the brain and the rest of the body. Symptoms of baclofen underdose (via intrathecal delivery) include itching, hypotension, paresthesias, fever, and altered mental state. If you miss a dose, take it as soon as you remember if it is within about 1 hour of that scheduled dose. The drug is rapidly absorbed after oral administration and is widely distributed throughout the body. Biotransformation is low and the drug is predominantly excreted in the unchanged form by the kidneys.
Side Effects of Baclofen
The following side effects of Baclofen may includes:
Warnings and precautions before taking Baclofen
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