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Generic Name

  • Caffeine and ergotamine.

Brand Name

  • Cafatine, Cafergot, Cafetrate, Ercaf, Migergot, Wigraine. 

General Information

Cafetrate is used to prevent and to treat vascular headaches such as migraine and migraine-like headaches. Caffeine and ergotamine both cause vasoconstriction (narrowing) of arteries and veins that supply blood to the head. This medication may cause dependence, especially if it has been used regularly for an extended time (more than a few weeks) or if it has been used in high doses. Caffeine and ergotamine may also be used for purposes other than those listed in this medication guide. Caffeine and ergotamine may be habit forming when used for long periods of time. Larger doses may be needed for headache relief, and withdrawal effects may occur when caffeine and ergotamine therapy is stopped.

Cafetrate Dosage

  • The dose of Cafetrate will be different for different patients.
  • Dosage is based on your medical condition and response to therapy.
  • The maximum dose is 2 suppositories for a single headache attack and 5 suppositories in any 7-day period.

Side Effects of Cafetrate

The following side effects of Cafetrate may includes:

  • Nausea or vomiting.
  • Muscle pain in the arms or legs.
  • Chest pain.
  • Leg weakness.
  • Fever or chills.
  • Changes in heart rate.
  • Rectal discomfort or sores.

Warnings and precautions before taking Cafetrate

  • Do not use Cafetrate if you are allergic to any ingredient in Cafetrate.
  • Do not take Cafetrate without first talking to your doctor if you are breast feeding a baby.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: abnormal heart rhythm, smoking, diarrhea, diabetes, high blood pressure, stomach problems.
  • Do not take caffeine and ergotamine if you are pregnant or if you could become pregnant during treatment.
  • Do not use more than six tablets or two suppositories per headache. Do not use more than ten tablets or five suppositories in seven days. If your symptoms are not being adequately treated, talk to your doctor.
  • If you are going to have any type of surgery, tell your prescriber or health care professional that you are taking caffeine; ergotamine.


  • After taking Cafetrate, If you feel that overdose is suspected, then contact with your doctor immediately.
  • Symptoms of a Cafetrate overdose include nausea, vomiting, numbness in the fingers or toes, confusion, drowsiness, convulsions, and possibly death.
  • Canadian residents should call their local poison control center directly.
  • US residents can call the US national poison hotline at 1-800-222-1222.



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