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Generic Name

  • Dacarbazine.

Brand Names

  • Dtic-Dome.

General Information

Dacarbazine is an anticancer (cytotoxic) medicine. It belongs to the group of medicines called alkylating agents. It is used to treat cancer of the lymph system and malignant melanoma (a type of skin cancer). It may also be used to treat other kinds of cancer, as determined by your doctor. Dacarbazine is also used to treat soft-tissue sarcomas such as leiomyosarcoma, fibrosarcoma, and rhabdomyosarcoma; neuroblastomas; and malignant glucagonoma. Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability of your body to fight infection or disease). Like most powerful drugs, it may produce more common side effects like nausea, fatigue, headache, etc. It is not known whether dacarbazine passes into breast milk. However, because this medicine may cause serious side effects, breast-feeding is generally not recommended while you are receiving it.

Dacarbazine Dosage

  • The dose of dacarbazine will be different for different patients.
  • The dose that is used may depend on a number of things, including what the medicine is being used for, the patient's weight, and whether or not other medicines are also being taken.
  • Dacarbazine is given as a shot in a vein over 20 minutes or longer.

Side Effects of Dacarbazine

The following side effects of Dacarbazine may includes:

  • Blood in urine or stools.
  • Lower back or side pain.
  • Loss of appetite.
  • Unusual bleeding or bruising.
  • Itching and rash.
  • Nausea and vomiting.
  • Sore throat.

Warning and precautions before taking Dacarbazine

  • Do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.
  • Tell your doctor and pharmacist if you are allergic to dacarbazine or any other drugs.
  • Do not take dacarbazine without first talking to your doctor if you are pregnant or thinking about becoming pregnant.
  • Tell your doctor if you have or have ever had liver disease.
  • Do not take dacarbazine without first talking to your doctor if you are breast feeding a baby.


  • If for any reason an overdose of dacarbazine is suspected, seek emergency medical attention or contact your healthcare provider immediately.
  • Symptoms of a dacarbazine overdose tend to be similar to side effects caused by the medication, although often more severe.
  • If the victim has collapsed or is not breathing, call local emergency services at 911.



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